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Assays, reagents, kits, and other assorted products used to detect cellular apoptosis, determine the activity levels of caspase or cathepsin, or identify similar cellular activity.
Human MASP1 Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human MASP1.
Human CD105 Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human CD105.
MW 509 Da, Purity >98%. Potent and selective inhibitor against caspase-1 with Ki of 0.8 nM. Orally absorbed. Also inhibits IL-1β release from both PBMCs and whole blood with IC50 of 0.67 μM and 1.9 μM, in vitro. Inhibits LPS-induced IL-1β production in collagen-induced arthritis mouse model, in vivo.
Human SGK1 Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human SGK1.
Human/Monkey Von Willebrand Factor Antibody Pair -BSA and Azide free is a kit for ELISA development for the quantitative measurement of Human/Monkey Von Willebrand Factor Antibody Pair -BSA and Azide free.
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This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits large and small that dimerize to form the active enzyme This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1 a cytokine involved in the processes such as inflammation septic shock and wound healing This gene has been shown to induce cell apoptosis and may function in various developmental stages Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease Alternative splicing results in transcript variants encoding distinct isoforms
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Caspase-3/7 Inhibitor I (CAS 220509-74-0) is a reversible inhibitor of caspase-3 and caspase-7 structurally belonging to the isatin sulfonamide class It exhibits selective inhibition toward caspase-3 and caspase-7 with Ki values of 60 nM and 170 nM respectively while minimally affecting caspase-9 (Ki 3 1 mM) and showing negligible activity against other caspases (caspases 1 2 4 6 and 8 Ki 25 mM) In cell-based assays this inhibitor effectively reduces apoptosis induced by camptothecin in Jurkat cells (IC50 50 M) and markedly suppresses apoptosis in chondrocytes at similar concentrations The compound is routinely utilized in apoptosis research and may offer therapeutic insights into apoptotic modulation
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Human C9 Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human C9.
Human CD13 Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human CD13.
Calcineurin B/PPP3R1 Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Calcineurin B/PPP3R1.
Robo2 Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Robo2.
Human Antithrombin III / ATIII Antibody Pair - BSA and Azide free is a kit containing recombinant capture and detector antibodies in a carrier-free formulation for the measurement of Human Antithrombin III / ATIII.